HCID 11379002, Verbindung → HCID 178513055, Verbindung

HRID 898815Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 898815
C[O:2][C:3]([C:5]1[O:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)=O.CS(O)(=O)=O.FC1C=CC=CC=1C1OC(C([NH:36][C:37]([NH2:39])=[NH:38])=O)=CC=1>CO.[Cl-].[Na+].O>[F:16][C:13]1[CH:14]=[CH:15][C:10]([C:7]2[O:6][C:5]([C:3]([NH:38][C:37]([NH2:39])=[NH:36])=[O:2])=[CH:9][CH:8]=2)=[CH:11][CH:12]=1

Komponenten

5

Edukt 2

HCID 11379002HCID 11379002, VerbindungHCID 178505355HCID 178505355, Verbindung

Produkt 1

HCID 178513055HCID 178513055, VerbindungAusbeute 51,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

5-(4-fluorophenyl)furan-2-carboxylic acid methyl ester (220 mg, 1.0 mmol) was dissolved in methanol (4 ml), to which 2 M guanidine solution (3.0 ml, 6.0 mmol) prepared in Example 1 was added, and the mixture was heated at reflux for 12 hours. After completion of the reaction, the solution was added with saturated brine (20 ml) and extracted with ethyl acetate (30 ml×3). The organic layer was washed with 10% brine, dried over anhydrous magnesium sulfate (MgSO4), and concentrated in vacuo. The residue was purified by silica gel column chromatography (5% methanol/dichloromethane), to give 127 mg of a title compound (yield: 51%).

Aufarbeitung

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureat reflux for 12 hours
  4. customAfter completion of the reaction
  5. extractionextracted with ethyl acetate (30 ml×3)
  6. washThe organic layer was washed with 10% brine
  7. dry with materialdried over anhydrous magnesium sulfate (MgSO4)
  8. concentrationconcentrated in vacuo
  9. customThe residue was purified by silica gel column chromatography (5% methanol/dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-df06d6e6b2ca4bd898935427db93b9e9
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07351843B2

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