Trifluoroacetic acid → Methyl 5-amino-2-hydroxypentanoate

HRID 899049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 899049
C(O)(C(F)(F)F)=O.[CH3:8][O:9][C:10](=[O:24])[CH:11]([OH:23])[CH2:12][CH2:13][CH2:14][NH:15]C(OC(C)(C)C)=O>C(Cl)Cl>[CH3:8][O:9][C:10](=[O:24])[CH:11]([OH:23])[CH2:12][CH2:13][CH2:14][NH2:15]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 543300255-Tert-butoxycarbonylamino-2-hydroxy-pentanoic acid methyl ester

Produkt 1

HCID 54185808Methyl 5-amino-2-hydroxypentanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

TFA (2 mL) was added to a solution of 5-tert-butoxycarbonylamino-2-hydroxy-pentanoic acid methyl ester in methylene chloride (10 mL) and the mixture was stirred for 3 h and then concentrated under reduced pressure to give crude 5-amino-2-hydroxy-pentanoic acid methyl ester (1 g).

Aufarbeitung

  1. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1dba90dc5cb4467f92220c7b7478df83
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07354895B1

Notizen zur Reaktion

Wird geladen…