Hydrochloric Acid → N-[3-(4-Cyanophenyl)propyl]-N-[2-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]methanesulfonamide, hydrochloride salt

HRID 899119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 899119
C(OC([N:8]1[CH2:15][CH:14]2[O:16][CH:10]([CH2:11][N:12]([CH2:17][CH2:18][N:19]([CH2:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=3)[S:20]([CH3:23])(=[O:22])=[O:21])[CH2:13]2)[CH2:9]1)=O)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[C:33]([C:30]1[CH:31]=[CH:32][C:27]([CH2:26][CH2:25][CH2:24][N:19]([CH2:18][CH2:17][N:12]2[CH2:13][CH:14]3[O:16][CH:10]([CH2:9][NH:8][CH2:15]3)[CH2:11]2)[S:20]([CH3:23])(=[O:22])=[O:21])=[CH:28][CH:29]=1)#[N:34]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 690720537-(2-{[3-(4-Cyanophenyl)propyl]methanesulfonylamino}ethyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester

Produkt 1

HCID 69077585N-[3-(4-Cyanophenyl)propyl]-N-[2-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]methanesulfonamide, hydrochloride salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

7-(2-{[3-(4-cyanophenyl)propyl]methanesulfonylamino}ethyl)-9-oxa-3,7-di-azabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (3.8 g, 0.0095 mol; see step (i) above) was added to a saturated solution of HCl(g) in ethyl acetate (50 mL) and the resultant mixture was then stirred overnight. On completion of the reaction (as determined by TLC), ethyl acetate was decanted and the product was dried under high vacuum to give the title compound. Yield: 1.5 g (54%).

Aufarbeitung

  1. customwas decanted
  2. customthe product was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-409804f3bba5495a8605586aa564ed97
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07354917B2

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