4-Aminophenyl trifluoromethyl sulphone → (s)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate

HRID 899948

Reaktionsgleichung

Reaktionsgleichung von HRID 899948
[NH:1]([C:8](OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=[O:9])[C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][OH:4].[CH3:25][C:26]1[CH:27]=[N:28][CH:29]=[CH:30][C:31]=1[CH:32]=O.[F:34][C:35]([F:47])([F:46])[S:36]([C:39]1[CH:45]=[CH:44][C:42]([NH2:43])=[CH:41][CH:40]=1)(=[O:38])=[O:37]>>[F:34][C:35]([F:47])([F:46])[C:5]([OH:7])=[O:6].[CH3:5][C@@H:2]1[N:1]([CH2:32][C:31]2[CH:30]=[CH:29][N:28]=[CH:27][C:26]=2[CH3:25])[C:8](=[O:9])[N:43]([C:42]2[CH:44]=[CH:45][C:39]([S:36]([C:35]([F:46])([F:34])[F:47])(=[O:37])=[O:38])=[CH:40][CH:41]=2)[C:3]1=[O:4]

Komponenten

4

Edukt 3

HCID 1363154-Aminophenyl trifluoromethyl sulphoneHCID 15018803-Methylpyridine-4-carbaldehydeHCID 6541433(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoic acid

Produkt 1

HCID 87566774(s)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate

Versuchsvorschrift

The compound is prepared from 0.04 mmol of resin, 0.12 mmol of N-Fmoc-L-Ala(OH), 0.20 mmol of 3-methyl-4-pyridinecarboxaldehyde, and 0.10 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 16 mg of expected product are obtained.

Aufarbeitung

  1. customAfter purification by preparative LC-MS, 16 mg of expected product
  2. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-490ffb2c646c43bb9b0e5ac59d517f4c
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07354933B2

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