1,8-Diazabicyclo(5.4.0)undec-7-ene → (Tert-butoxy)-n-[4-(2,4-dioxo(1,3-dihydroquinazolin-3-yl))phenyl]carboxamide

Beteiligte Stoffe

Reaktionsschritte

To a solution of methyl 2-isocyanatobenzoate (0.97 g, 5.5 mmol) and Boc 1,4-phenylenediamine (1.04 g, 5 mmol) in THF (15 mL) was added DIEA (0.87 mL, 5 mmol) and DBU (0.75 mL, 5 mmol). The reaction mixture stirred at room temp for 5 hr. the off-white solid filtered and washed with ethyl ether to give desired compound (1.49 g, 85%). ES-MS (M+Na)+=376.1, (M-tBu+H)+=298.0.

Herkunft & Nachweise