Trifluoroacetic acid → 3-(4-Aminophenyl)-1,3-dihydroquinazoline-2,4-dione trifluoroacetate

HRID 900294

Reaktionsgleichung

Reaktionsgleichung von HRID 900294
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:24](=[O:25])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16]2=[O:26])=[CH:11][CH:10]=1)=O)(C)(C)C.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>C(Cl)Cl>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:24](=[O:25])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16]2=[O:26])=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 91580089(Tert-butoxy)-n-[4-(2,4-dioxo(1,3-dihydroquinazolin-3-yl))phenyl]carboxamide

Produkt 1

HCID 220643913-(4-Aminophenyl)-1,3-dihydroquinazoline-2,4-dione trifluoroacetateAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a chilled suspension of (tert-butoxy)-N-[4-(2,4-dioxo(1,3-dihydroquinazolin-3-yl))phenyl]carboxamide (0.35 g, 1 mmol) in CH2Cl2 (2 mL) was added neat TFA (2 ML). The resulting solution was stirred cold for 1 hr, concentrated in vacuo, azeotroped with heptane and dried to give desired compound (0.376 g, 99%) as the mono TFA salt. ES-MS (M+H)+=254.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. customazeotroped with heptane
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-453655a2aaea4c15aac83959ac76f4ea
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07358257B2

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