Methanol → 3-[(Aminocarbonyl)amino]-5-(2-hydroxyphenyl)-2-thiophenecarboxamide

HRID 900423Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 900423
[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16]C)[S:7][C:6]=1[C:18]([NH2:20])=[O:19])=[O:3].B(Br)(Br)Br.CO>ClCCl>[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[OH:16])[S:7][C:6]=1[C:18]([NH2:20])=[O:19])=[O:3]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 25134Boron tribromideHCID 9835679HCID 9835679, Verbindung

Produkt 1

HCID 179309823-[(Aminocarbonyl)amino]-5-(2-hydroxyphenyl)-2-thiophenecarboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

3-[(Aminocarbonyl)amino]-5-(2-methoxyphenyl)-2-thiophenecarboxamide (0.1 g), boron tribromide (2 ml of a 1M solution in dichloromethane) and dichloromethane (10 mL) were stirred at room temperature for 16 h. Methanol (5 mL) was added and after 1 h, the solvent was evaporated. 2M Hydrochloric acid (10 mL) was added and, after stirring for 1 h, the phenol was filtered off and used directly in step (b).

Aufarbeitung

  1. customthe solvent was evaporated
  2. addition2M Hydrochloric acid (10 mL) was added
  3. filtrationthe phenol was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-6631b47902cc406987bd878b64626c75
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07358376B2

Notizen zur Reaktion

Wird geladen…