3,5-Dichloro-4-hydroxybenzoic acid → 3-({1-[2-(3,5-Dichloro-4-hydroxybenzoylamino)-3-methanesulfonyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-oxo-butyric Acid

HRID 900561

Reaktionsgleichung

Reaktionsgleichung von HRID 900561
NC1C=CC(C([NH:8][CH:9]([CH2:27][S:28]([CH3:31])(=[O:30])=[O:29])[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH:13]2[C:17]([NH:19][CH:20]([CH:25]=[O:26])[CH2:21][C:22]([OH:24])=[O:23])=[O:18])=[O:11])=O)=CC=1Cl.[Cl:35][C:36]1[CH:37]=[C:38]([CH:42]=[C:43]([Cl:46])[C:44]=1[OH:45])[C:39]([OH:41])=O>>[Cl:46][C:43]1[CH:42]=[C:38]([CH:37]=[C:36]([Cl:35])[C:44]=1[OH:45])[C:39]([NH:8][CH:9]([CH2:27][S:28]([CH3:31])(=[O:30])=[O:29])[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][CH:13]1[C:17]([NH:19][CH:20]([CH:25]=[O:26])[CH2:21][C:22]([OH:24])=[O:23])=[O:18])=[O:11])=[O:41]

Komponenten

3

Edukt 2

HCID 187493,5-Dichloro-4-hydroxybenzoic acidHCID 186237713-({1-[2-(4-Amino-3-chloro-benzoylamino)-3-methylsulfonyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-oxo-butyric acid

Produkt 1

HCID 186237703-({1-[2-(3,5-Dichloro-4-hydroxybenzoylamino)-3-methanesulfonyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-4-oxo-butyric Acid

Versuchsvorschrift

Compound 20s was prepared according to the procedure used for the preparation of 20i, using 3,5-dichloro-4-hydroxybenzoic acid in place of 1-isoquinolinecarboxylic acid.

Quellen und Nachweise

ORD-Eintrag
ord-5e08b25201134761ab3b9297ce971fa1
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07358273B2

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