Ethyl 5-hydroxy-1H-indole-2-carboxylate → 5-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid

HRID 901091

Reaktionsgleichung

Reaktionsgleichung von HRID 901091
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH2:16][CH2:17][CH:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH3:23])=[CH:10][CH:9]=2)=[O:5])C.C(OC(C1NC2C(C=1)=CC(O)=CC=2)=O)C.CN1CCCC1CCO>>[CH3:23][N:19]1[CH2:20][CH2:21][CH2:22][CH:18]1[CH2:17][CH2:16][O:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:14]2

Komponenten

4

Edukt 3

HCID 90677Ethyl 5-hydroxy-1H-indole-2-carboxylateHCID 933631-Methyl-2-pyrrolidineethanolHCID 692832745-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl ester

Produkt 1

HCID 596994585-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid

Versuchsvorschrift

According to the procedure described for the synthesis of Example 5/step 1 5-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl ester was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (commercially available) and 2-(1-methyl-pyrrolidin-2-yl)-ethanol (commercially available). The title compound was yielded in 38% as light brown foam. MS (m/e): 317.1 (MH+, 100%).

Quellen und Nachweise

ORD-Eintrag
ord-d2a1405bff534b2d9435c2d5b0cbac55
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07361682B2

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