Hydrochloric Acid → 3-(Piperidin-4-yl)propan-1-ol hydrochloride
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:3][CH:2]=1.[ClH:11]>[Pt]=O>[ClH:11].[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][OH:10])[CH2:3][CH2:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1.00 g (7.29 mmol) of 4-pyridinepropanol was dissolved in 3N aqueous hydrochloric acid solution and 206 mg of platinum oxide was added thereto, followed by stirring of the mixture at room temperature under a hydrogen atmosphere at an ordinary pressure for 12 hours. The reaction mixture was filtered with Celite and the filtrate was distilled off under reduced pressure. The thus obtained residue was reprecipitated from methanol-ether to obtain 1.31 g (yield: quantitative) of the title compound as a white solid.
Aufarbeitung
- filtrationThe reaction mixture was filtered with Celite
- distillationthe filtrate was distilled off under reduced pressure
- customThe thus obtained residue was reprecipitated from methanol-ether
Quellen und Nachweise
- ORD-Eintrag
- ord-4b60620bf83045789194e22f531affcb
- Quelldatensatz
- uspto-grants-2008_04
- Patentnummer
- US07365067B2
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