Methanesulfonic Acid → (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[6-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propyl}-amine dimesylate salt

HRID 902651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 902651
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[C:12]([OH:14])[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:15]1([CH:21]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:22][N:23]([CH2:36][CH2:37][CH2:38]O)[CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[C:26]=2[Cl:35])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.OC1C=C(C=CC=1)CC1N(COCC)N=NN=1.BrCCCO.[CH3:68][S:69]([OH:72])(=[O:71])=[O:70]>ClCCl>[S:69]([OH:72])(=[O:71])(=[O:70])[CH3:68].[S:69]([OH:72])(=[O:71])(=[O:70])[CH3:68].[Cl:35][C:26]1[C:27]([C:31]([F:32])([F:33])[F:34])=[CH:28][CH:29]=[CH:30][C:25]=1[CH2:24][N:23]([CH2:22][CH:21]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH2:36][CH2:37][CH2:38][O:14][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([N:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)[N:13]=1

Komponenten

7

Edukt 5

HCID 6395Methanesulfonic AcidHCID 123083-Bromo-1-propanolHCID 577571173-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propan-1-olHCID 688254685-(3-Hydroxy-benzyl)-ethoxymethyl-1,2,3,4-tetrazoleHCID 178480672HCID 178480672, Verbindung

Produkt 1

HCID 86598286(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[6-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propyl}-amine dimesylate salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Following the procedure of Example 6(d), except 6-(4-methyl-piperazin-1-yl)-pyridin-2-ol and N-(2,2-Diphenylethyl)-N-(3-hydroxy-propyl)-N-(2-chloro-3-trifluoromethyl-benzyl)amine were used instead of 5-(3-hydroxy-benzyl)-ethoxymethyl-1,2,3,4-tetrazole and 3-bromo-propanol in step 6(d), the title compound was synthesized as the free base. The tertiaryamine was then dissolved in dichloromethane and two equivalents of methanesulfonic acid were added to afford the title compound as the dimesylate salt, 47 mg (19% yield), as a white solid. MS (ESI) 623.4 (M+).

Aufarbeitung

  1. customthe title compound was synthesized as the free base

Quellen und Nachweise

ORD-Eintrag
ord-69d7d342c37b44f9a7e3b40a2974405e
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07365085B2

Notizen zur Reaktion

Wird geladen…