Methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate → 4-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoic acid
Reaktionsgleichung
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=2)[S:6][CH:7]=1>Cl>[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:16][CH:17]=2)[S:6][CH:7]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
An aqueous solution of HCl (6N, 200 mL) was added to methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate (20.0 g, 0.075 mol) and refluxed overnight. The reaction mixture was allowed to cool to ambient temperatures and the solid was filtered and then dried in vacuo at 40° C. to give the title compound (15.0 g, 75%).
Aufarbeitung
- temperaturerefluxed overnight
- temperatureto cool to ambient temperatures
- filtrationthe solid was filtered
- customdried in vacuo at 40° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-838eed514c4e41c08fac337aa0623775
- Quelldatensatz
- uspto-grants-2008_04
- Patentnummer
- US07365225B2
Notizen zur Reaktion
Wird geladen…