Ethyl bromoacetate → Glycine, N-(4-chlorophenyl)-, ethyl ester

HRID 902864

Reaktionsgleichung

[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][CH:3]=1

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

4-Chloroaniline (2.0 g) was dissolved in acetonitrile (20 ml), and ethyl bromoacetate (2.1 g) and potassium carbonate (2.2 g) were added to stir the mixture at 60° C. for 2 days. The reaction mixture was filtered through Celite pad, and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1) to obtain the title compound (2.3 g).

Aufarbeitung

filtrationThe reaction mixture was filtered through Celite pad
concentrationthe filtrate was concentrated under reduced pressure
customThe resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1)

Quellen und Nachweise

ORD-Eintrag: ord-5ec36d3d26a1439cae354690b211cd5c
Quelldatensatz: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07365205B2

Verknüpfte Notizen

Wird geladen…