Hydrochloric Acid → HCID 15313948, Verbindung

HRID 903116Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 903116
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14](N)=[O:15].Cl.[C:21](=O)(O)[O-:22].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([O:22][CH3:21])=[O:15]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 233376972-(2-Chloro-4-trifluoromethylphenylamino)-3-methylbutyramide

Produkt 1

HCID 15313948HCID 15313948, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutyramide (1 mmol) and 4 ml of methanol, saturated with HCl gas, is heated at 75° for about 40 hours. The mixture is cooled, poured into saturated aqueous sodium bicarbonate and extracted with ether. The combined ether extracts are dried over sodium sulfate and solvent removed in vacuo to yield methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, which can be further purified by prep. thin layer chromatography.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. extractionextracted with ether
  3. dry with materialThe combined ether extracts are dried over sodium sulfate and solvent
  4. customremoved in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4eef25e6ba7e4adaa88d56cebb91a18c
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04226802

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