Methyl Isocyanate → Fluzinamide

HRID 903132Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 903132
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH:7]1[CH2:10][NH:9][CH2:8]1.[CH3:16][N:17]=[C:18]=[O:19]>C1C=CC=CC=1>[CH3:16][NH:17][C:18]([N:9]1[CH2:10][CH:7]([O:6][C:5]2[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:1])([F:14])[F:15])[CH:4]=2)[CH2:8]1)=[O:19]

Komponenten

4

Edukt 2

HCID 12228Methyl IsocyanateHCID 111385383-[3-(Trifluoromethyl)phenoxy]azetidine

Produkt 1

HCID 53467Fluzinamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To 6.0 g. (0.024 mole) of 3-(3-trifluoromethylphenoxy) azetidine in 50 ml. of dry benzene was added dropwise 1.37 g. (0.024 mole) of methylisocyanate with stirring, and stirring was continued for 30 minutes. The solid which crystallized in the flask was recrystallized using 95% ethanol to give 5.0 g. (76%) of product (m.p. 145°-147° C.).

Aufarbeitung

  1. customThe solid which crystallized in the flask
  2. customwas recrystallized
  3. customto give 5.0 g

Quellen und Nachweise

ORD-Eintrag
ord-868b300370dd4c3f90fca1ffe2ead79d
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04226861

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