Hydrochloric Acid → 7-Chloro-10-[(6-dimethylaminohexyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride

HRID 903145

Reaktionsgleichung

Reaktionsgleichung von HRID 903145
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](Cl)=[C:7]3[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:8]3=[N:9][C:10]=2[CH:11]=1.[CH3:19][N:20]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][NH2:28])[CH3:21].C1(O)C=CC=CC=1.[ClH:36]>CC(C)=O.C(O)C>[ClH:1].[ClH:36].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]([NH:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][N:20]([CH3:21])[CH3:19])=[C:7]3[N:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:8]3=[N:9][C:10]=2[CH:11]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 996PhenolHCID 231071-Aza-6,9-dichloro-2-methoxyacridineHCID 2585446-(Dimethylamino)hexylamine

Produkt 1

HCID 233378147-Chloro-10-[(6-dimethylaminohexyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2.8 g. of 7,10-dichloro-2-methoxypyrido [3,2-b]quinoline, 1.5 g. of dimethylaminohexylamine and 6.5 g. of phenol is stirred and heated on a steam bath for 3 hours. The mixture is cooled, 20 ml. of ethanol are added and the dark solution is poured into a mixture of 200 ml. of acetone and 2.5 ml. of concentrated hydrochloric acid. The mixture is cooled in ice. The solid is collected, air-dried and recrystallized from 3A alcohol:acetone (50:50), giving the desired product as yellow crystals, mp. 243°-244° C. (dec.).

Aufarbeitung

  1. additionA mixture of 2.8 g
  2. temperatureheated on a steam bath for 3 hours
  3. temperatureThe mixture is cooled
  4. additionthe dark solution is poured into a mixture of 200 ml
  5. temperatureThe mixture is cooled in ice
  6. customThe solid is collected
  7. customair-dried
  8. customrecrystallized from 3A alcohol:acetone (50:50)

Quellen und Nachweise

ORD-Eintrag
ord-498878e22acd4646ad34eac2c127fbcc
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04226869

Verknüpfte Notizen

Wird geladen…