HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Formaldehyde → (1,4-dimethyl-1H-imidazol-2-yl)methanol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Formaldehyde | HCID 712 | — |
| Edukt | 1,4-Dimethylimidazole | HCID 138733 | — |
| Edukt | (5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-3-yl)methanol | HCID 12923422 | — |
| Edukt | Butyllithium | HCID 178418339 | — |
| Produkt | (1,4-dimethyl-1H-imidazol-2-yl)methanol | HCID 12923402 | — |
Reaktionsschritte
The reaction of 1,4-dimethylimidazole (5.65 g.) with n-butyl lithium followed by treatment with formaldehyde according to the method described for the preparation of 3hydroxymethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine (used for Example 224) gave 1,4-dimethyl-2-hydroxymethylimidazol (2.71 g.), m.p. 125°-126° (ethyl acetate-petroleum ether).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04226874 |
| Quelldatensatz | uspto-grants-1980_10 |
| ORD ID | ord-78df6d84ad7f49ec90f9642b03ca7c90 |
| Quellennotiz | uspto-grants-1980_10 |