Chloride → 4-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate

HRID 903412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 903412
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[Cl-].Cl.[CH:18]1([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]2[CH:41]=[CH:40][C:36]([C:37](Cl)=[O:38])=[CH:35][CH:34]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C(Cl)Cl>[CH:18]1([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]2[CH:41]=[CH:40][C:36]([C:37]([O:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[O:38])=[CH:35][CH:34]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Komponenten

6

Edukt 4

HCID 312ChlorideHCID 46844-ChlorophenolHCID 8471TriethylamineHCID 20475769p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride

Produkt 1

HCID 204758364-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 6.4 g. 4-chlorophenol and 7.6 g. triethylamine in 500 ml. meythlene chloride is added 10.4 g. 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in 250 ml. methylene chloride. After four hours at reflux, the solution is cooled, washed with water and dilute phosphoric acid, and dried. After passing the solution through a column of alumina, the solvent is evaporated an the residue is crystallized from diisopropyl ether.

Aufarbeitung

  1. temperatureAfter four hours at reflux
  2. temperaturethe solution is cooled
  3. washwashed with water and dilute phosphoric acid
  4. customdried
  5. customthe solvent is evaporated an the residue
  6. customis crystallized from diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-3940520d066b43778c8bea81293339ff
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04227014

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