Chlorosulfonic acid → 2-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

HRID 903561Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 903561
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].[Cl:14][S:15](O)(=[O:17])=[O:16]>>[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([S:15]([Cl:14])(=[O:17])=[O:16])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 24638Chlorosulfonic acidHCID 6002152-Acetyl-1,2,3,4-tetrahydroisoquinoline

Produkt 1

HCID 126069042-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

N-Acetyl-1,2,3,4-tetrahydroisoquinoline (180 gm., 1.03 m.) was added slowly to 800 gms. (6.9 m.) of chlorosulfonic acid and stirred at -50° C. The solution was stirred at 25° C. for two days, poured onto crushed ice and extracted with ethyl acetate. The extract was washed, dried over anhydrous sodium sulfate and evaporated to yield crude N-acetyl-7-chlorosulfonyl-1,2,3,4-tetrahydroisoquinoline.

Aufarbeitung

  1. additionpoured
  2. customonto crushed ice
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed
  5. dry with materialdried over anhydrous sodium sulfate
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-ac3a5073eeba45afae1730de4844130e
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04228170

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