Methylamine → N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine

HRID 903749Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 903749
[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[CH:16]=[CH:15][S:14][N:13]=1)SC)#[N:2].[CH3:17][NH2:18]>>[C:1]([NH:3][C:4]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[CH:16]=[CH:15][S:14][N:13]=1)=[N:18][CH3:17])#[N:2]

Komponenten

3

Edukt 2

HCID 6329MethylamineHCID 20567647N-cyano-N'-[2-(3isothiazolylmethylthio)ethyl]-S-methylisothiourea

Produkt 1

HCID 9992541N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine

Versuchsvorschrift

The reaction of N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-S-methylisothiourea (0.27 g.) with excess methylamine according to the procedure described in Example 3(c) and recrystallisation of the product from ispropyl acetate afforded N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine (0.12 g.), m.p. 91°-93°. (Found: C, 42.4; H, 5.1; N, 27.3; S, 25.2. C9H13N5S2 requires: C, 42.3; H, 5.1; N, 27.4; S, 25.1).

Aufarbeitung

  1. customdescribed in Example 3(c) and recrystallisation of the product from ispropyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-193644c50793407c9f32a72401efbdb9
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04228291

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