3,5-Dichlorophenyl isocyanate → 2-Ethyl-3-(3,5-dichlorophenylcarbamoyl) thiazolidine-2-carboxylic acid methyl ester

HRID 903889

Reaktionsgleichung

Reaktionsgleichung von HRID 903889
[CH3:1][O:2][C:3]([C:5]1([CH2:10][CH3:11])[NH:9][CH2:8][CH2:7][S:6]1)=[O:4].[Cl:12][C:13]1[CH:14]=[C:15]([N:20]=[C:21]=[O:22])[CH:16]=[C:17]([Cl:19])[CH:18]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1([CH2:10][CH3:11])[N:9]([C:21](=[O:22])[NH:20][C:15]2[CH:16]=[C:17]([Cl:19])[CH:18]=[C:13]([Cl:12])[CH:14]=2)[CH2:8][CH2:7][S:6]1)=[O:4]

Komponenten

4

Edukt 2

HCID 944603,5-Dichlorophenyl isocyanateHCID 217820732-Ethyl thiazolidine-2-carboxylic acid methyl ester

Produkt 1

HCID 539706522-Ethyl-3-(3,5-dichlorophenylcarbamoyl) thiazolidine-2-carboxylic acid methyl esterAusbeute 78,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 0.62 g of the 2-ethyl thiazolidine-2-carboxylic acid methyl ester thus obtained, 0.66 g of 3,5-dichlorophenyl isocyanate and 10 ml of toluene was stirred at room temperature for 1 hour. Then, the precipitate was filtered to give 1.00 g (yield 77.8%) of 2-ethyl-3-(3,5-dichlorophenylcarbamoyl) thiazolidine-2-carboxylic acid methyl ester with a melting point of 187°-188° C. The results of the elementary analysis were as follows: Found (calculated in parentheses): C 46.48% (46.29%), H b 4.35% (4.44%), N 7.50% (7.71%), Cl 19.86% (19.52%).

Aufarbeitung

  1. customthus obtained
  2. filtrationThen, the precipitate was filtered

Quellen und Nachweise

ORD-Eintrag
ord-1e6abf34231043f49e5b3cbe2b23f20a
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04229461

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