Dimethylamine → [(4-tert-Butyl-phenyl)-(1-methyl-1H-indol-3-yl)-methyl]-dimethyl-amine

HRID 9042

Reaktionsgleichung

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[Cl-].[C:12]([C:16]1[CH:25]=[CH:24][C:19]([CH:20]=[N+:21]([CH3:23])[CH3:22])=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13].C(C1C=CC(C=O)=CC=1)(C)(C)C.CNC>>[C:12]([C:16]1[CH:17]=[CH:18][C:19]([CH:20]([N:21]([CH3:23])[CH3:22])[C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)=[CH:24][CH:25]=1)([CH3:15])([CH3:13])[CH3:14]

Komponenten

Edukt 4

HCID 674Dimethylamine

HCID 117811-Methylindole

HCID 703244-tert-Butylbenzaldehyde

HCID 21985368(4-Tert-butyl-benzylidene)-dimethylammonium chloride

Produkt 1

HCID 21985357[(4-tert-Butyl-phenyl)-(1-methyl-1H-indol-3-yl)-methyl]-dimethyl-amine

Versuchsvorschrift

The preparation was carried out in accordance with general synthesis instructions 4 from 1-methylindole and (4-tert-butyl-benzylidene)-dimethyl-ammonium chloride, which had been prepared in accordance with example 24 from 4-tert-butyl-benzaldehyde and dimethylamine.

Quellen und Nachweise

ORD-Eintrag: ord-cd3d1d7842614bdcaa46121f99044cdb
Quelldatensatz: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07091220B2

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