Sodium Cyanide → 12-Hydroxydodecanenitrile

HRID 904240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 904240
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[C-:14]#[N:15].[Na+]>CN(C)C=O>[OH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:14]#[N:15]

Komponenten

4

Edukt 2

HCID 8929Sodium CyanideHCID 7416311-Bromo-1-undecanol

Produkt 1

HCID 1033034812-Hydroxydodecanenitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution 4.6 g. of 11-bromoundecanol and 1.6 g. of sodium cyanide in 40 ml. of dimethylformamide is heated at 80° C. for 18 hours, cooled, and poured into ice-water. The mixture is extracted with methylene chloride and the extract is dried over anhydrous magnesium sulfate. Evaporation of the solution affords 12-hydroxydodecanonitrile as a yellow oil.

Aufarbeitung

  1. temperaturecooled
  2. extractionThe mixture is extracted with methylene chloride
  3. dry with materialthe extract is dried over anhydrous magnesium sulfate
  4. customEvaporation of the solution

Quellen und Nachweise

ORD-Eintrag
ord-af4d2d2762314fcc986794205f24620b
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04230628

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