Timonacic → 3-[4-(4-Pentadecenylamino)benzoyl]-4-carboxythiazolidine

HRID 904499

Reaktionsgleichung

Reaktionsgleichung von HRID 904499
[CH2:1]([NH:16][C:17]1[CH:34]=[CH:33][C:20]([C:21]([N:23]2[CH:27]([C:28]([O:30]CC)=[O:29])[CH2:26][S:25][CH2:24]2)=[O:22])=[CH:19][CH:18]=1)[CH2:2][CH2:3][CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:16][C:17]1[CH:18]=[CH:19][C:20]([C:21]([N:23]2[CH:27]([C:28]([OH:30])=[O:29])[CH2:26][S:25][CH2:24]2)=[O:22])=[CH:33][CH:34]=1)[CH2:2][CH2:3][CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Komponenten

4

Edukt 2

HCID 9934TimonacicHCID 536530283-[4-(4-Pentadecenylamino)benzoyl]-4-carboethoxythiazolidine

Produkt 1

HCID 538355243-[4-(4-Pentadecenylamino)benzoyl]-4-carboxythiazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 86737261Acetone sodium bicarbonateLösungsmittel

Versuchsvorschrift

By means of the alkaline hydrolysis method of Example 2 the ethyl ester of Example 385 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 385 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

Aufarbeitung

  1. customThis acid is also prepared

Quellen und Nachweise

ORD-Eintrag
ord-a25f4f14ee584281bdb91b5e95b0134e
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04230878

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