Dimethylamine → {(2-Chloro-6-fluoro-phenyl)-[2-(4-chloro-phenyl)-1H-indol-3-yl]-methyl}-dimethyl-amine

HRID 9046

Reaktionsgleichung

Reaktionsgleichung von HRID 9046
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:4][CH:3]=1.[Cl-].[Cl:18][C:19]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:20]=1[CH:21]=[N+:22]([CH3:24])[CH3:23].ClC1C=CC=C(F)C=1C=O.CNC>>[Cl:18][C:19]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:20]=1[CH:21]([N:22]([CH3:24])[CH3:23])[C:16]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1

Komponenten

5

Edukt 4

HCID 674DimethylamineHCID 678472-Chloro-6-fluorobenzaldehydeHCID 2204632-(4-Chlorophenyl)-1H-indoleHCID 21985312(2-Chloro-6-fluoro-benzylidene)-dimethylammonium chloride

Produkt 1

HCID 21985282{(2-Chloro-6-fluoro-phenyl)-[2-(4-chloro-phenyl)-1H-indol-3-yl]-methyl}-dimethyl-amine

Versuchsvorschrift

The preparation was carried out in accordance with general synthesis instructions 4 from 2-(4-chlorophenyl)-indole and (2-chloro-6-fluoro-benzylidene)-dimethyl-ammonium chloride, which had been prepared in accordance with example 24 from 2-chloro-6-fluoro-benzaldehyde and dimethylamine.

Quellen und Nachweise

ORD-Eintrag
ord-481423226194464382ed5e4c678c6fee
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091220B2

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