Acetic Anhydride → 2-Pyrrolidinone, 1-acetyl-

Beteiligte Stoffe

Reaktionsschritte

A mixture of 112 g of 2-pyrrolidinone (9) and 249 mL of acetic anhydride was heated at reflux for 2 hours. The resultant mixture was allowed to cool to room temperature, was concentrated in vacuo, and was distilled (0.8 mm Hg, 68° C.) to provide 160 g of N-acetyl-2-pyrrolidinone (4) in 96% yield.

Herkunft & Nachweise