Hydrochloric Acid → 1-(2,2,2-Trifluoroethyl)piperidin-3-amine hydrochloride

HRID 905962Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 905962
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:9]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[F:18][C:15]([F:16])([F:17])[CH2:14][N:10]1[CH2:11][CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67386443Racemic [1-(2,2,2-trifluoro-ethyl)-piperidin-3-yl]-carbamic acid tert-butyl ester

Produkt 1

HCID 673862671-(2,2,2-Trifluoroethyl)piperidin-3-amine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

[1-(2,2,2-Trifluoro-ethyl)-piperidin-3-yl]-carbamic acid tert-butyl ester (0.380 g, 1.3 mmol) was dissolved in 3 mL of dioxane. A 4 M solution of HCl in dioxane (3.3 mL, 13.3 mmol) was added and the resulting mixture was stirred overnight at RT before being evaporated to give racemic 1-(2,2,2-trifluoro-ethyl)-piperidin-3-ylamine hydrochloride.

Aufarbeitung

  1. custombefore being evaporated

Quellen und Nachweise

ORD-Eintrag
ord-3f03c2486ef24a91ac3d7b9ec87fd4ff
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08012974B2

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