Trifluoroacetic acid methylene chloride → HCID 67414694, Verbindung

HRID 906037Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 906037
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)=C)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(Cl)Cl.[C:36]([OH:42])([C:38]([F:41])([F:40])[F:39])=[O:37]>>[F:39][C:38]([F:41])([F:40])[C:36]([O-:42])=[O:37].[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][NH2+:23][CH2:22][CH2:21]3)=[CH:16][CH:15]=2)=[O:37])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 57439883HCID 57439883, Verbindung

Produkt 1

HCID 67414694HCID 67414694, VerbindungAusbeute 95 %

Versuchsvorschrift

tert-butyl 4-[4-(1-{[4-(acetyloxy)phenyl]amino}vinyl)phenyl]piperazine-1-carboxylate (0.1 M) in a solution of DCM/TFA (2/3) was stirred at RT for 30 min. The organic solvent was evaporated in vacuo and the crude residue was scratched with Et2O. The resultant white solid precipitate was filtered off to afford the title compound (95%); MS (ES+) m/z 339 (M+H)+

Aufarbeitung

  1. customThe organic solvent was evaporated in vacuo
  2. filtrationThe resultant white solid precipitate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-a9eb63e8e30246309e29765be4102858
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08012982B2

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