Methyl iodide → 5,5-Dimethyl-2-methylsulphanyl-3,4,5,6-tetrahydropyrimidinium hydroiodide

HRID 906226

Reaktionsgleichung

Reaktionsgleichung von HRID 906226
[CH3:1][C:2]1([CH3:9])[CH2:7][NH:6][C:5](=[S:8])[NH:4][CH2:3]1.[I:10][CH3:11]>CO>[IH:10].[CH3:1][C:2]1([CH3:9])[CH2:7][NH+:6]=[C:5]([S:8][CH3:11])[NH:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 38664875,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol

Produkt 1

HCID 866001675,5-Dimethyl-2-methylsulphanyl-3,4,5,6-tetrahydropyrimidinium hydroiodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The reaction mixture comprising one equivalent of 5,5-dimethyl-3,4,5,6-tetrahydro(1H)pyrimidine-2-thione and 1.2 equivalents of iodomethane in methanol (10 ml/g of thio-urea) is heated under reflux for 5 hours. After cooling down, the methanol is evaporated off under reduced pressure in order to quantitatively produce the product. The precipitate can then be washed in acetone or petroleum ether.

Aufarbeitung

  1. temperatureunder reflux for 5 hours
  2. temperatureAfter cooling down
  3. customthe methanol is evaporated off under reduced pressure in order
  4. customto quantitatively produce the product
  5. washThe precipitate can then be washed in acetone

Quellen und Nachweise

ORD-Eintrag
ord-74e08c4ab9b149f9950b4f135f462d6e
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08012985B2

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