Hydrochloric Acid → Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

HRID 906486Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 906486
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[H-].[Na+].Cl.[CH:18](OCC)=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:18][OH:19])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 11481060Ethyl 2-(3,5-difluorophenyl)acetate

Produkt 1

HCID 67388060Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

Versuchsvorschrift

5.0 g of ethyl 3,5-difluorophenylacetate are dissolved in 50 ml of ethyl formate. 2.0 g of 60% NaH are added portionwise. The mixture is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. The residue is triturated in petroleum ether, the remaining white precipitate is filtered off and then the filtrate is evaporated to produce 3.3 g of the expected compound in the form of a liquid.

Aufarbeitung

  1. extractionextraction
  2. customThe residue is triturated in petroleum ether
  3. filtrationthe remaining white precipitate is filtered off
  4. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-7aea890950ef439393eeb37a0b9fc503
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08012991B2

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