Tert-butyl 4-(4-chloro-1,2,5-thiadiazol-3-yl)piperazine-1-carboxylate → 1-(4-Chloro-[1,2,5]thiadiazol-3-yl)piperazine hydrochloride

HRID 907542

Reaktionsgleichung

Reaktionsgleichung von HRID 907542
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:18]([Cl:19])=[N:17][S:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:19].[Cl:19][C:18]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][S:16][N:17]=1

Komponenten

4

Edukt 1

HCID 15524001Tert-butyl 4-(4-chloro-1,2,5-thiadiazol-3-yl)piperazine-1-carboxylate

Produkt 1

HCID 212020421-(4-Chloro-[1,2,5]thiadiazol-3-yl)piperazine hydrochlorideAusbeute 191,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-(4-Chloro-[1,2,5]thiadiazol-3-yl)piperazine-1-carboxylic acid tert-butyl ester (1.0 g, 3.28 mmol) was suspended in 10 mL of 4 M HCl in dioxane. The suspension was stirred overnight and the solid material was removed by filtration. The solid was washed three times with 15 mL ethyl acetate and dried under vacuum. 756 mg of white powder was obtained.

Aufarbeitung

  1. customthe solid material was removed by filtration
  2. washThe solid was washed three times with 15 mL ethyl acetate
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2e205e0847fa4600a4b442f995ea3e82
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08013156B2

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