Hydrochloric Acid → HCID 58446922, Verbindung

HRID 908231Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 908231
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]([CH3:19])[N:10]=[CH:11][C:12]=1[C:13]([N:15]1[CH2:18][CH2:17][CH2:16]1)=[O:14])=[O:7])C.Cl.[Na+].[Cl-]>C1COCC1>[N:15]1([C:13]([C:12]2[CH:11]=[N:10][N:9]([CH3:19])[C:8]=2[C:6]([OH:7])=[O:5])=[O:14])[CH2:18][CH2:17][CH2:16]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 67041800ethyl 4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylate

Produkt 1

HCID 58446922HCID 58446922, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

NaOH (1N, 10 ml) was added to a solution of 4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (1.32 g, 5.0 mmol) in THF (50 ml), and the mixture was stirred at r.t. (3.5 h). The mixture was neutralized by addition of HCl (1N, 10 ml). The mixture was evaporated under vacuum and the title compound, containing theoretically 2 equiv. of NaCl, (1.72 g, 99%) was used in Step 6 without further purification. MS (m/e)=210.2 [M+H+].

Aufarbeitung

  1. customThe mixture was evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-8549ca19a572413c87c2426f9bcb4212
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017604B2

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