5-Dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one → 3-(4,5-Dihydro-2-oxa-1,3,7,9-tetraaza-cyclopenta[a]naphthalen-8-ylamino)-phenol

HRID 908357

Reaktionsgleichung

Reaktionsgleichung von HRID 908357
CN([CH:4]=[C:5]1[C:13](=O)[C:9]2=[N:10][O:11][N:12]=[C:8]2[CH2:7][CH2:6]1)C.[OH:15][C:16]1[CH:17]=[C:18]([NH:22][C:23]([NH2:25])=[NH:24])[CH:19]=[CH:20][CH:21]=1>CN(C=O)C>[N:10]1[O:11][N:12]=[C:8]2[CH2:7][CH2:6][C:5]3[C:13](=[N:24][C:23]([NH:22][C:18]4[CH:17]=[C:16]([OH:15])[CH:21]=[CH:20][CH:19]=4)=[N:25][CH:4]=3)[C:9]=12

Komponenten

4

Edukt 2

HCID 674055215-Dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-oneHCID 178418735HCID 178418735, Verbindung

Produkt 1

HCID 114032713-(4,5-Dihydro-2-oxa-1,3,7,9-tetraaza-cyclopenta[a]naphthalen-8-ylamino)-phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The DMF solution of 5-dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one 0.1 g (0.00052 mol) and 3 equivalents of N-(3-hydroxy-phenyl)-guanidine was stirred at 110° C. for overnight, the final product was purified by directly injecting the DMF reaction solution into prep HPLC.

Aufarbeitung

  1. customthe final product was purified
  2. customthe DMF reaction solution into prep HPLC

Quellen und Nachweise

ORD-Eintrag
ord-57a5be34e2c14092ba998626ea8640c0
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017619B2

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