Hydrochloric Acid → HCID 11186874, Verbindung

HRID 908823Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 908823
C[O:2][C:3](=[O:25])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10]([Cl:24])[C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7].Cl.C([O-])(O)=O.[Na+]>>[Cl:24][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:8]([C:6]([NH:5][CH2:4][C:3]([OH:25])=[O:2])=[O:7])[N:9]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 86014604HCID 86014604, Verbindung

Produkt 1

HCID 11186874HCID 11186874, VerbindungAusbeute 73,4 %

Versuchsvorschrift

A mixture of [(1-chloro-4-phenyl-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (50 mg, 0.14 mmol, Example D-74 b), and aqueous 6N HCl was stirred at ambient temperature for 11 days before the solution was neutralized by the addition of concentrated aqueous NaHCO3. The mixture was extracted with EtOAc (50 ml). The organic phase was dried over MgSO4 and concentrated in vacuo to give the title compound as a white solid (35 mg); MS-(+)-ion: M+1=341.0.

Aufarbeitung

  1. extractionThe mixture was extracted with EtOAc (50 ml)
  2. dry with materialThe organic phase was dried over MgSO4
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f8bf767803fb441bb09c4ef9167678d3
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017625B2

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