Methylamine → HCID 178482759, Verbindung

HRID 909002Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 909002
[Cl:1][C:2]1[C:3]([F:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:11][NH2:12]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([F:10])=[C:4](/[CH:5]=[N:12]/[CH3:11])[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 7363353-Chloro-2-fluorobenzaldehyde

Produkt 1

HCID 178482759HCID 178482759, VerbindungAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 3-chloro-2-fluoro-benzoaldehyde (Oakwood, 97%) (1.59 g, 10.0 mmol) and methyl amine (2.0 M in THF, Aldrich, 7.5 mL, 15.0 mmol) in CH2Cl2 (20 mL) was stirred at rt overnight. The reaction mixture was concentrated and the residue was dried under reduced pressure to afford [[1-(3-chloro-2-fluoro-phenyl)-meth-(E)-ylidene]-methyl-amine (1.72 g, 100%) as colorless oil which was used in the next step without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6d55a2d313e340b49ff7ea2f9f82a35e
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017607B2

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