Methylamine → HCID 178482786, Verbindung

HRID 909004Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 909004
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([F:10])[CH:3]=1.[CH3:11][NH2:12]>C(Cl)Cl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[N:12]/[CH3:11])=[C:4]([F:10])[CH:3]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 27249084-Chloro-2-fluorobenzaldehyde

Produkt 1

HCID 178482786HCID 178482786, VerbindungAusbeute 129 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 4-chloro-2-fluoro-benzoaldehyde (Matrix Sci, 3.17 g, 20.0 mmol) and methyl amine (2.0 M in THF, Aldrich, 15 mL, 15.0 mmol) in CH2Cl2 (20 mL) was stirred at rt overnight. The reaction mixture was concentrated and the residue was dried under reduced pressure to afford [[1-(4-chloro-2-fluoro-phenyl)-meth-(E)-ylidene]-methyl-amine (3.32 g, 97.0%) as colorless oil which was used in the next step without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1d20a16282d04d55b250733efc63a97b
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017607B2

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