Aluminium lithium hydride → HCID 67409860, Verbindung

HRID 909241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 909241
[Si:1]([O:8][C:9]([CH3:31])([CH3:30])[CH2:10][N:11]1[C:19]2[C:14](=[CH:15][C:16]([O:20][C:21]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=3[C:23]#[N:24])=[CH:17][CH:18]=2)[CH:13]=[N:12]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[Si:1]([O:8][C:9]([CH3:31])([CH3:30])[CH2:10][N:11]1[C:19]2[C:14](=[CH:15][C:16]([O:20][C:21]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=3[CH2:23][NH2:24])=[CH:17][CH:18]=2)[CH:13]=[N:12]1)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 674118002-{1-[2-(tert-butyldimethylsilanyloxy)-2-methyl-propyl]-1H-indazol-5-yloxy}-5-fluorobenzonitrile

Produkt 1

HCID 67409860HCID 67409860, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a cooled (0° C.) solution of 2-{1-[2-(tert-butyldimethylsilanyloxy)-2-methyl-propyl]-1H-indazol-5-yloxy}-5-fluorobenzonitrile (0.071 g, 0.162 mmol) in THF (2 mL) was added LAH (0.32 mL of 1M in THF). The solution was warmed to room temperature and stirred for 1 hour. The reaction mixture was cooled to 0° C. and quenched with water (12 μL), 3N NaOH (12 μL) and water (36 μL). The salts were removed by filtration and the filtrate was concentrated under reduced pressure and used in the next reaction without further purification.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to 0° C.
  2. customquenched with water (12 μL), 3N NaOH (12 μL) and water (36 μL)
  3. customThe salts were removed by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customused in the next reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b7063d94756b4efd8ae26263375d3ea3
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017641B2

Notizen zur Reaktion

Wird geladen…