tert-Butyl methyl ether → 1,2-Benzenediol, 4-(3-hydroxypropyl)-

HRID 909697

Reaktionsgleichung

Reaktionsgleichung von HRID 909697
O[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([OH:12])[C:8](=[CH:10][CH:11]=1)[OH:9])=O.[CH3:13][O:14]C(C)(C)C>>[CH:11]1[C:5]([CH2:3][CH2:2][CH2:13][OH:14])=[CH:6][C:7]([OH:12])=[C:8]([OH:9])[CH:10]=1

Komponenten

3

Edukt 2

HCID 15413tert-Butyl methyl etherHCID 221344442-Hydroxy-3′,4′-dihydroxyacetophenone

Produkt 1

HCID 112174641,2-Benzenediol, 4-(3-hydroxypropyl)-

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

A special house made pressure reactor, a 50 ml 10 bar glass reactor with steel mantle and a magnetic stirring bar, was charged with catalyst, 4-hydroxyacetyl-catechol (produced according to Example 2) and t-butyl methyl ether. The reactor was evacuated and filled with hydrogen. Hydrogenation was started by stirring at 5 bar hydrogen pressure while heating to 40° C. By the end of the reaction the hydrogen was replaced by air, the slurry was filtered, the catalyst was washed with ethyl acetate. After evaporation of the solvents and drying at 1 mbar the product was analyzed quantitatively. The details of some reactions and the results are shown in Table 1.

Aufarbeitung

  1. customThe reactor was evacuated
  2. additionfilled with hydrogen
  3. customBy the end of the reaction the hydrogen
  4. filtrationthe slurry was filtered
  5. washthe catalyst was washed with ethyl acetate
  6. customAfter evaporation of the solvents
  7. customdrying at 1 mbar the product

Quellen und Nachweise

ORD-Eintrag
ord-3c54dba0bde4486c8305ae18deb44e6c
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017815B2

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