Hydrochloric Acid → 4-(1-Methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid

HRID 910608Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 910608
[OH-].[Na+].[CH3:3][N:4]1[CH:9]=[CH:8][C:7](=[O:10])[C:6]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17]C)=[O:16])=[CH:13][CH:12]=2)=[CH:5]1.Cl>CCO>[CH3:3][N:4]1[CH:9]=[CH:8][C:7](=[O:10])[C:6]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=2)=[CH:5]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57583987Methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate

Produkt 1

HCID 575840694-(1-Methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acidAusbeute 84,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1 M NaOH (1.42 ml) was added to an EtOH suspension (3 ml) of methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate (115 mg), followed by stirring at room temperature for 8 hours. 1 M HCl (1.42 ml) was added to the reaction solution, followed by concentration under reduced pressure. Water (20 ml) was added to the residue, followed by stirring for 20 minutes. The precipitate formed was collected by filtration and dried under reduced pressure at 60° C. to obtain 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid (92 mg).

Aufarbeitung

  1. concentrationfollowed by concentration under reduced pressure
  2. additionWater (20 ml) was added to the residue
  3. stirringby stirring for 20 minutes
  4. customThe precipitate formed
  5. filtrationwas collected by filtration
  6. customdried under reduced pressure at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-93825d8b1fd04ca68dd31dbe8ae0f235
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022208B2

Notizen zur Reaktion

Wird geladen…