Zytron → HCID 86624412, Verbindung

HRID 910761

Reaktionsgleichung

Reaktionsgleichung von HRID 910761
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH2:11])[CH3:10])=[CH:5][CH:4]=1.CC(NP(OC1C=CC(Cl)=CC=1Cl)(OC)=S)C.[CH2:29]=[C:30]1[O:33][C:32](=[O:34])[CH2:31]1>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:32](=[O:34])[CH2:31][C:30](=[O:33])[CH3:29])[CH3:10])=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 9299ZytronHCID 12661DiketeneHCID 793467(S)-1-(4-Methoxyphenyl)ethylamine

Produkt 1

HCID 86624412HCID 86624412, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To a solution of (S)-1-(4-methoxy-phenyl)-ethylamine (25 g) in dichloromethane (60 mL) was added TEA (20 g) and DMPA (200 mg). Then a solution of 4-methylene-oxetan-2-one (16.7 g) in dichloromethane (60 ml) was added over a period of 30 minutes and then stirred at 20° C. for 18 h. The mixture was washed with 1M HCl, aq. NaHCO3 and aq. NaCl. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.

Aufarbeitung

  1. washThe mixture was washed with 1M HCl, aq. NaHCO3 and aq. NaCl
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fdd2daeea4e04186afc19c09f929978c
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022218B2

Verknüpfte Notizen

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