Ammonium Acetate → (s)-3-Amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide

HRID 910762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 910762
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:17])[CH2:13][C:14](=O)[CH3:15])[CH3:10])=[CH:5][CH:4]=1.C([O-])(=O)C.[NH4+:22]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:17])[CH:13]=[C:14]([NH2:22])[CH3:15])[CH3:10])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 517165Ammonium AcetateHCID 86624412(1S)-N-[1-(4-Methoxy-phenyl)-ethyl]-3-oxo-butyramide

Produkt 1

HCID 67417518(s)-3-Amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a suspension of (S)—N-[1-(4-methoxy-phenyl)-ethyl]-3-oxo-butyramide (10 g) in toluene (800 ml) was added at 20° C. ammonium acetate (10 g) and the reaction was heated for 20 h at 100° C. in a Dean Stark system. The mixture was concentrated in vacuo and the product obtained was used without further purification in the following reaction step.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe product obtained
  3. customwas used without further purification in the following reaction step

Quellen und Nachweise

ORD-Eintrag
ord-604860e08133494c8cb94413d7eda6e1
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022218B2

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