4-Amino-2-methylquinoline → 3-[7-(2-Methyl-quinolin-4-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol

HRID 912086

Reaktionsgleichung

Reaktionsgleichung von HRID 912086
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.CC1C=C(N)C2C(=CC=CC=2)N=1.C[O:38][C:39]1[CH:40]=[C:41]([C:45]2[C:46]3[CH2:59][CH2:58][N:57]([C:60]4[C:69]5[C:64](=[CH:65][CH:66]=[CH:67][CH:68]=5)[N:63]=[C:62]([CH3:70])[CH:61]=4)[C:47]=3[N:48]=[C:49]([N:51]3[CH2:56][CH2:55][O:54][CH2:53][CH2:52]3)[N:50]=2)[CH:42]=[CH:43][CH:44]=1>>[CH3:70][C:62]1[CH:61]=[C:60]([N:57]2[C:47]3[N:48]=[C:49]([N:51]4[CH2:52][CH2:53][O:54][CH2:55][CH2:56]4)[N:50]=[C:45]([C:41]4[CH:40]=[C:39]([OH:38])[CH:44]=[CH:43][CH:42]=4)[C:46]=3[CH2:59][CH2:58]2)[C:69]2[C:64](=[CH:65][CH:66]=[CH:67][CH:68]=2)[N:63]=1

Komponenten

4

Edukt 3

HCID 811164-Amino-2-methylquinolineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 673865864-[4-(3-Methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-quinoline

Produkt 1

HCID 248890933-[7-(2-Methyl-quinolin-4-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol

Versuchsvorschrift

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2-methyl-quinolin-4-ylamine, 4-[4-(3-methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-2-methyl-quinoline was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-d2b0cc6453b4456ba7879daec7ebafed
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022205B2

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