Methyl iodide → (S)-tert-butyl 1-methyl-2-oxoazepan-3-ylcarbamate

Reaktionsgleichung

[O:1]=[C:2]1[C@@H:8]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][CH2:6][CH2:5][CH2:4][NH:3]1.[CH3:17]I>>[CH3:17][N:3]1[CH2:4][CH2:5][CH2:6][CH2:7][C@H:8]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[C:2]1=[O:1]

Komponenten

Edukt 2

HCID 6328Methyl iodide

HCID 7022178(S)-tert-Butyl (2-oxoazepan-3-yl)carbamate

Produkt 1

HCID 60110341(S)-tert-butyl 1-methyl-2-oxoazepan-3-ylcarbamate

Versuchsvorschrift

(S)-tert-butyl 1-methyl-2-oxoazepan-3-ylcarbamate was prepared from (S)-tert-butyl 2-oxoazepan-3-ylcarbamate (Example 8) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 50% ethyl acetate/hexanes, to provide compound (2e) in 48% yield.

Aufarbeitung

customThe crude product was purified by column chromatography
washeluting with 50% ethyl acetate/hexanes

Quellen und Nachweise

ORD-Eintrag: ord-9f0d9d2e4b70443b888feff9bec15f44
Quelldatensatz: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08026233B2

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