Hydrochloric Acid → 4-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid

HRID 912513Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 912513
O1CCCCC1[O:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:19])[OH:18])=[CH:13][C:12]=1[C:20]([F:23])([F:22])[F:21].Cl>>[OH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:18])[OH:19])=[CH:13][C:12]=1[C:20]([F:23])([F:21])[F:22]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 576575904-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid

Produkt 1

HCID 576575404-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

4-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid (8 g) was added to hydrochloric acid (1M in MeOH) and the mixture was heated at 60° C. for 60 minutes. Solvent and HCl was then removed under reduced pressure and residue (5.52 g) was used for next step without further purification.

Aufarbeitung

  1. customSolvent and HCl was then removed under reduced pressure and residue (5.52 g)
  2. customwas used for next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-85e19f2c4ac64c40a4820a4a0ef464a7
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026236B2

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