O-Methylhydroxylamine hydrochloride → 5-tert-butyl-1-indanone O-methyloxime

HRID 912629

Reaktionsgleichung

Reaktionsgleichung von HRID 912629
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=O)[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:16][O:17][NH2:18]>N1C=CC=CC=1>[CH3:16][O:17][N:18]=[C:10]1[C:11]2[C:7](=[CH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:13][CH:12]=2)[CH2:8][CH2:9]1

Komponenten

4

Edukt 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

Produkt 1

HCID 730474605-tert-butyl-1-indanone O-methyloxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

5-tert-Butyl-1-indanone (13.41 g, 71.23 mmol) and methoxyamine hydrochloride (6.68 g, 80 mmol) were disolved in pyridine (75 ml) and stirred at ambient temperature for 16 hours. The mixture was evaporated under reduced pressure and the residue was partitioned between water and diethyl ether (X2). The combined organic layers were washed with 1N aqueous hydrochloric acid, dried with magnesium sulfate, and the filtrate was evaporated under reduced pressure to provide the title compound which was used without further purification in the next step.

Aufarbeitung

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue was partitioned between water and diethyl ether (X2)
  3. washThe combined organic layers were washed with 1N aqueous hydrochloric acid
  4. dry with materialdried with magnesium sulfate
  5. customthe filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-21d60427599a4c2cb94d0b704c1d126c
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026256B2

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