Ethyl [(phenoxycarbonyl)oxy]acetate → 2-(Ethyloxy)-2-oxoethyl 4-{2-[(4-bromophenyl)oxy]ethyl}-1-piperidinecarboxylate

HRID 912742

Reaktionsgleichung

Reaktionsgleichung von HRID 912742
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.[CH2:17]([O:19][C:20](=[O:32])[CH2:21][O:22][C:23](OC1C=CC=CC=1)=[O:24])[CH3:18]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH2:9][CH2:10][CH:11]2[CH2:12][CH2:13][N:14]([C:23]([O:22][CH2:21][C:20]([O:19][CH2:17][CH3:18])=[O:32])=[O:24])[CH2:15][CH2:16]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetateHCID 568302784-{2-[(4-Bromophenyl)oxy]ethyl}-piperidine

Produkt 1

HCID 674150252-(Ethyloxy)-2-oxoethyl 4-{2-[(4-bromophenyl)oxy]ethyl}-1-piperidinecarboxylateAusbeute 54,6 %

Versuchsvorschrift

The procedure described in Example 4.3. is repeated. Starting from 1.76 g (6.19 mmol) of 4-{2-[(4 bromophenyl)oxy]ethyl} prepared in Step 9.2., and 1.39 g (6.19 mmol) of ethyl{[(phenyloxy)carbonyl]oxy}-acetate, prepared in accordance with Example 1.1., gives 1.4 g of product in oil form.

Quellen und Nachweise

ORD-Eintrag
ord-5322c33b4e1d4ae89a8e6cd29b527c1c
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026258B2

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