Hydrochloric Acid → 1-(3-Chloropyridin-2-yl)piperazine hydrochloride

HRID 912764

Reaktionsgleichung

Reaktionsgleichung von HRID 912764
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.CCOC(C)=O>[ClH:20].[Cl:20][C:19]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][CH:16]=[CH:17][CH:18]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

Produkt 1

HCID 204550741-(3-Chloropyridin-2-yl)piperazine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of the ester from step (a) above (2.98 g, 10 mmol) in MeOH (5 mL) was added saturated solution of hydrogen chloride in EtOAc (50 mL) and the mixture was stirred at room temperature for 4 h. The solvent was removed in vacuo, and the residue was washed with EtOAc and dried in the air to provide the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 198 (M+1).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. washthe residue was washed with EtOAc
  3. customdried in the air

Quellen und Nachweise

ORD-Eintrag
ord-c93b2a1e0f454847a3ddf9c15a5091aa
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026241B2

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