HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,5-Dichlorobenzimidazole → 6-Chloro-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,5-Dichlorobenzimidazole | HCID 335473 | — |
| Edukt | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | — |
| Produkt | 6-Chloro-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 11559986 | — |
Reaktionsschritte
The benzoimidazole from step (b) above (0.186 g, 0.995 mmol) and 1-(3-trifluoromethylpyridin-2-yl)piperazine (0.23 g, 0.995 mmol, Maybridge) reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 228-231° C. MS (ESI, pos. ion) m/z: 382 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08026241B2 |
| Quelldatensatz | uspto-grants-2011_09 |
| ORD ID | ord-928ae9136f824508b92e7532c87f4533 |
| Quellennotiz | uspto-grants-2011_09 |