3-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid → 5-(benzyloxy)-2-methylpyridin-4(1H)-one

HRID 913003

Reaktionsgleichung

Reaktionsgleichung von HRID 913003
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[CH:13]=[C:12]([CH3:16])[NH:11][C:10]=1C(O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CN(C=O)C>[CH2:1]([O:8][C:9]1[C:14](=[O:15])[CH:13]=[C:12]([CH3:16])[NH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 672824263-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid

Produkt 1

HCID 63247195-(benzyloxy)-2-methylpyridin-4(1H)-oneAusbeute 77,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A suspension of 3-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid (3.2 g, 0.02 mol) in DMF (30 ml) was heated in an oil bath at 120° C. for 8 hrs. The mixture was cooled to room temperature and the insoluble solid was filtered. The solid was washed with hexane and dried under vacuum for 16 hrs to give 5-benzyloxy-2-methyl-1H-pyridin-4-one (3.32 g, 77% yield).

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe insoluble solid was filtered
  3. washThe solid was washed with hexane
  4. customdried under vacuum for 16 hrs

Quellen und Nachweise

ORD-Eintrag
ord-3fdb4b6614ac4bc1b9aaaebcbce71486
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026261B2

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