Acetyl chloride → Dimethyl acetylphosphonate

HRID 913206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 913206
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][P:7]([O:10]C)[O:8][CH3:9]>>[C:1]([P:7](=[O:10])([O:8][CH3:9])[O:6][CH3:5])(=[O:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 6367Acetyl chlorideHCID 8472Trimethyl phosphite

Produkt 1

HCID 2785315Dimethyl acetylphosphonate

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Acetyl chloride (7.85 ml, 110 mmol) was cooled to 0° C. and stirred. Trimethylphosphite (11.8 ml, 100 mmol) was added drop-wise over one hour while the cooling was maintained. The mixture was then heated to 80° C. for 5 minute to remove un-reacted acetyl chloride (the flow of argon accelerates the process). The crude product was used in the next step without additional purification (theoretical yield is 15.2 g).

Aufarbeitung

  1. temperaturewas maintained
  2. customto remove
  3. customun-reacted acetyl chloride (the flow of argon
  4. customThe crude product was used in the next step without additional purification (theoretical yield is 15.2 g)

Quellen und Nachweise

ORD-Eintrag
ord-8a98fc38509e461d81c3130a305f5db4
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026278B2

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